Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice

Dimethyl fumarate for ischemic stroke

In a series of proof-of-concept experiments using in vitro and in vivo models of ischemic stroke, we provide evidence that dimethyl fumarate (DMF) strongly reduces neuronal cell death upon ischemic insult through pleiotropic anti-inflammatory and cytoprotective effects [1, 2]. DMF is a derivative of the fumaric acid, an intermediate product of the citric acid cycle. DMF is marketed as Tecfidera...

Dimethyl sulfoxide, diethyl fumarate solution for high dose dosimetry

Background: Dosimetry is a fundamental part of the radiation processing industry. Aqueous inorganic dosimeters have been used for gamma radiation dosimetry such as standard ferrous sulfate dosimeter. The purpose of this study was to investigate the effect of gamma radiation on the diethyl fumarate DEF in dimethyl sulfoxide DMSO solution and its possible use in chemical dosimetry. Materials and ...

Dimethyl fumarate for relapsing-remitting multiple sclerosis.

For many years the only drugs licensed for the treatment of multiple sclerosis (MS) were administered by injection (interferon beta, glatiramer and ▼natalizumab). Recently, three oral drugs have become available. We have previously reviewed the use of ▼fingolimod for highly active relapsing-remitting MS1 and ▼teriflunomide for the management of relapsing-remitting MS in adults.2 Here, we review...

Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity

In vitro harnessing of immune cells is the most important advance in the field of cancer immunotherapy. Results shown in the current paper may be used to harness natural killer (NK) cells in vitro. It is observed that drugs used to treat multiple sclerosis such as glatiramer acetate, dimethyl fumarate, and monomethyl fumarate upregulate the expression of chemokines receptor 10 (CCR10) on the su...

Persistent shoe dermatitis caused by dimethyl fumarate.